a tool for identifying drug-targetable redox-active disulphides

Angiogenin-1

Intramolecular

Cysteine 50 and cysteine 105

A redox-regulated disulphide may form within Angiogenin-1 between cysteines 50 and 105 (27 and 82 respectively in this structure).

Details

Redox score ?

84

PDB code

Structure name

crystal structure of bovine angiogenin at 1

Structure deposition date

1995-01-06

Thiol separation (Å)

2

Half-sphere exposure sum ?

79

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

50

Residue number B

105

Peptide name

Angiogenin-1

Ligandability

Cysteine 50 of Angiogenin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of Angiogenin-1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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